I-Tianeptine Sodium CAS: 30123-17-2 5-dioxide Stablon S-Dioxide Sodium Ityuwa

SEBENZISA

Ityuwa ye-sodium ye-Tianeptine yi-tricyclic antidepressant, kwaye indlela yayo yokunciphisa uxinzelelo yahlukile kwi-tricyclic antidepressants yendabuko.Inokunyusa ukubuyiswa kwakhona kwe-5-HT kwindawo ye-synaptic, kwaye ingaba nefuthe lokuphucula ukuqhutyelwa kwe-5-HT neurons.Akukho budlelwane kwi-choline okanye i-adrenaline receptors.Ukusebenza kwe-Antidepressant kufana ne-tricyclic, kodwa ukunyamezela kungcono kune-tricyclic.Kuvavanyo lwezilwanyana, inokunyusa umsebenzi ozenzekelayo weeseli zepyramidal kwi-hippocampus kwaye ikhawulezise ukubuyiswa kwayo emva kokuthintela umsebenzi.I-Chemicalbook yonyusa ukuphinda kufakwe i-serotonin ngama-neurons kwi-cerebral cortex kunye ne-hippocampus.Ukufunxwa kwe-tineptine sodium kwi-digestive tract ikhawuleza kwaye iphelele.Ukuhanjiswa okukhawulezayo, iPPB ukuya kuthi ga kwi-94%.I-metabolized ngokupheleleyo kwisibindi nge-β-oxidation kunye ne-N-demethylation, kunye nokukhutshwa kwe-terminal T1 / 2 yayimfutshane kwi-2.5h.Isixa esincinci kakhulu sechiza (8%) sakhutshwa kwizintso, ikakhulu i-metabolites yayo kumchamo.Izigulane ezinokusilela kwezintso zicinywe i-T1/2 kangange-1h eyandisiweyo.