I-Teduglutide CAS: 197922-42-2 i-Revestive ALX 0600 Gattex

Umsebenzi:
I-Teduglutide, eyaziwa ngesiNgesi njenge-Teduglutide, i-analogue ye-glucagon-like peptide 2 (GLP-2), ihomoni eyenzeka ngokwemvelo enciphisa ukukhupha isisu kunye nokukhupha kunye nokulawula ukukhula, ukwanda, kunye nokulungiswa kweeseli kwi-intestinal lining.Ichiza kwandisa inani ezi seli, okwandisa ukufunxa emathunjini amancinci kunye nokunciphisa urhudo.
Ukulungiselela:
Ukwenziwa kwesakhiwo seringi esinamalungu amahlanu sinxulumene kakhulu ne-amino acid echanekileyo ye-Asp okanye i-Asn, kwaye i-Gly sesona sakhiwo sisesenziwe lula xa i-Gly idityaniswa ngaphambi kwe-Asp ngenxa yokungabikho kweqela elikhuselayo kunye nesithintelo esisezantsi se-steric ecaleni. ikhonkco.Ngoko ke, akunakuphepheka ukuba indlela yokudibanisa ngokulandelelana iya kwenza i-N-terminal amino acids ye-Teduchemicalbook lupeptide yenza i-ring-five-member in process of synthesis, ngaloo ndlela inciphisa ukucoceka.Ngoko ke, ukwenzela ukucombulula ingxaki yokuthotywa kwe-Asp-Gly fragment, iqhekeza elikhuselwe ngokupheleleyo kunye nesakhiwo esiboniswe kwi-SEQIDNO: i-2 yaqala ukuhlanganiswa ngokudibanisa iqhekeza.Iqhekeza elikhuselwe ngokupheleleyo yayiyeyokuqala ~ yesine ye-amino acid yokuqala ye-N-terminal ye-tidulutide, kubandakanywa nolwakhiwo lwe-Asp-Gly, emva koko iqhekeza elikhuselwe ngokupheleleyo lacocwa.Isiqwenga esisulungekisiweyo esikhuselwe ngokupheleleyo sasiyinqanaba eliqinileyo elidityaniswe neqhekeza le-peptide resin kunye nesakhiwo esiboniswe kwi-SEQIDNO: 12, kunye ne-cleavage yokugqibela yaqhutyelwa ukufumana i-tidurotide.