I-China inikezela nge-Lidocaine CAS 137-58-6 ngexabiso eliphezulu
Ulwazi olusisiseko
Inyibilika kwi-ethanol, ether, benzene, chloroform kunye ne-oyile, ayinyibiliki emanzini.Isiseko esisetyenziswa ngokuqhelekileyo i-hydrochloride, i-lidocaine hydrochloride (C14H22N2O · HCL, [73-78-9]) i-crystalline powder emhlophe.Indawo yokunyibilika yi-127-129 ℃, kwaye indawo yokunyibilika ye-monohydrate yi-77-78 ℃.Inyibilika kakhulu emanzini, i-0.5% ene-aqueous pHO4.0-5.5.Ayinavumba, incasa yehemp ekrakra.
Ukusetyenziswa
Imveliso yi-amide ye-anesthetic yendawo.Isetyenziswa ngokubanzi kwi-anesthesia yendawo, i-anesthesia yokungena, i-anesthesia yokuqhuba kunye ne-epidural anesthesia.I-LD50 ye-lidocaine hydrochloride yayiyi-290mg/kg.
Izicelo zeklinikhi ziquka i-anesthesia yokungena, i-epidURAL anesthesia, i-anesthesia ye-topical (kuquka i-anesthesia ye-mucosal ngexesha le-thoracoscopy okanye utyando lwesisu), kunye ne-nerve block.I-epinephrine inokongezwa kwi-anesthetic yokwandisa ixesha le-anesthesia kunye nokunciphisa imiphumo emibi njengetyhefu nge-lidocaine.
I-Lidocaine ingasetyenziselwa ukuphatha i-ventricular arrhythmias emva kwe-acute myocardial infarction, kubandakanywa ukunyanzeliswa kwe-ventricular kwangaphambi kwexesha, i-tachycardia ye-ventricular, i-ventricular arrhythmias ebangelwa yi-digitalis poisoning, utyando lwe-cardiac kunye ne-catheterization ye-cardiac, kubandakanywa i-ventricular premature contractions, i-ventricular tachycardia kunye ne-ventricular tachycardia.Ikwasetyenziselwa izigulane ezinesimo se-epilepticus ezingaphenduliyo kwezinye i-anticonvulsants kunye ne-anesthesia yendawo okanye ye-intraspinal.Ngokuqhelekileyo ayisebenzi ngokuchasene ne-supraventricular arrhythmias.
Iinkcukacha
| Igama lemveliso | Lidocaine |
| CAS | 137-58-6 |
| MF | I-C14H22N2O |
| MW | 234.34 |
| EINECS | 205-302-8 |
| Indawo yokunyibilika | 66-69°C |
| Indawo yokubilisa | bp4 180-182 °;bp2 159-160 ° |
| ukuxinana | 0.9944 (uqikelelo olurhabaxa) |
| isalathiso se-refractive | 1.5110 (uqikelelo) |
| Fp | 9℃ |
| ixesha lokugcina. | Gcina eRT |
| ukunyibilika | i-ethanol: 4 mg/mL |
| pka | pKa 7.88(H2O)(Kuqikelelwa) |
| ifomu | umgubo |
| umbala | Mhlophe ukuya kumthubi kancinane |
| Ukunyibilika kwamanzi | ayinyibiliki ngokwenene |
| Merck | 14,5482 |
| Uzinzo: | Izinzile.Ayihambelani ne-oxidizing agents ezinamandla. |
| I-InChIKey | NNJVILVZKWQKPM-UHFFFAOYSA-N |
| CAS Database Reference | 137-58-6(I-CAS Database Reference) |