I-China Hot Sale CAS 7361-61-7 Xylazine cannabinoids umgubo omhlophe

Inkcazo

I-Xylazine i-agonist ye-α2-adrenergic receptors (Ki = 194 nM).I-analog ye-clonidine, i-α2-adrenergic receptor agonist esetyenziselwa ukunciphisa uxinzelelo lwegazi.I-Xylazine isetyenziselwa i-sedation, i-anesthesia, kunye ne-analgesia kwizilwanyana ezincelisayo ezingezona zomntu.Le mveliso ikwafumaneka njengomgangatho wereferensi yohlalutyo .
Umsunguli weXylazine, eBayer

Usebenzisa

I-Antinociceptive;I-agonist ye-adrenergic ye-Alpha-2
Usebenzisa

I-Xylazine yiklasi ye-α2 ye-adrenergic receptor agonist.I-Xylazine yi-analoque ye-clonidine esebenza kwi-presynaptic kunye ne-postsynaptic receptors njenge-agonist ye-2-adrenergic.
Inkqubo yokuVelisa

I-2,6-Dimethylphenyl isothiocyanate, i-31.0 g (i-0.2 i-mole), elungiselelwe ukusuka kwi-2,6- dimethylaniline kunye ne-thiophosgene, yongezwa i-dropwise ngexesha le-15 min ukuya kukumiswa kakuhle kwe-15.0 g (0.2 mole) ye-3-aminopropanol-1 I-100 ml ye-ether.I-ether yaqalisa ukubila.Ukuvuselela phantsi kwe-reflux kwaqhutyekwa kwi-30 min, kwaye i-ether emva koko yachithwa.Intsalela yaphathwa nge-100 ml ye-concentrated hydrochloric acid kwaye ibilisiwe phantsi kwe-reflux ye-30 min.Emva kokupholisa, yayihlanjululwe ngamanzi, yahluzwa ngaphandle kokungcola, kwaye isiseko sancitshiswa ngokongezwa kwesisombululo se-sodium hydroxide.Xa i-recrystallized ukusuka kwi-benzene-ligroin, i-compound eyi-2-(2,6- dimethyl-phenylamino) -4H-5,6-dihydro-1,3-thiazine, i-melting point 140-142 ° C (ivelise i-90% yethiyori. ).
Umsebenzi woNyango

I-analgesic, i-anesthetic

Inkcazo ngokubanzi

I-Xylazine i-soluble kwi-methanol (50 mg / ml), ivelisa isisombululo esicacileyo, esingenambala.Ikwanyibilika kwi-asidi ye-HCl edibeneyo kunye ne-chloroform.I-Xylazine ayinakunyibilika emanzini nakwizisombululo zealkali.
Izenzo zeBiochem/physiol

I-Xylazine xa isetyenziswe kunye ne-ketamine ithathwa njenge-anesthetic enamandla kwaye ekhuselekileyo kwisilwanyana sokulinga.Kuyaziwa ngokunyusa ukukhutshwa kweglucose kwisibindi, nto leyo enyusa i-hyperglycemia.
Indlela yokwenza

I-Xylazine ithengiswa njengetyuwa ye-hydrochloride njenge-Rompun (100 mg / mL) kunye ne-Anased (20 mg / mL) izisombululo ze-injection zokulawulwa kwe-intravenous kumahashe kunye nezinja, ngokulandelanayo.Izenzo ze-xylazine zingatshintshwa ngokulawulwa kwe-yohimbine, i-indoalkylamine alkaloid, evimba ezo α2-adrenoreceptors ezikhuthazwa yi-xylazine.
Inkangeleko yoKhuseleko

Ityhefu ngokutya, i-subcutaneous, kunye neendlela ezifakwe emithanjeni.Iimpembelelo zenkqubo yomntu: utshintsho kumsebenzi wemoto, ukuwa koxinzelelo lwegazi, i-miosis, ukuqina kwe-pleural, ukuncipha kwesantya sokubetha, ukulala.Xa ishushu ukuze ibole ikhupha imisi eyityhefu kakhulu ye-NOx kunye ne-SOx