China Intengiso eshushu CAS 2160555-52-0 5CAKB48 cannabinoids amandla amhlophe

IKhemistri

I-5F-AKB48, okanye i-N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide, i-synthetic indazolecarboxamide njengoko iqulethe iqela le-indazole elifakwe endaweni.Le moeity ye-indazole ifakwa endaweni ye-R1 ngetsheyini ye-fluoropentyl, endaweni ekwabelwana ngayo ne-5F-PB-22.Ukongeza, i-indazole ifakwa endaweni ye-R3 kunye neqela le-carboxamide.Eli qela le-carboxamide lifakwe endaweni ye-N kwiqela le-amine ye-terminal kunye neqela le-adamantane.Eli qela liqulathe amakhonkco amane e-cyclohexane edityanisiweyo kwisakhiwo esisodwa esibizwa ngokuba yi-diamoid.I-5F-AKB48 yi-analog ye-STS-135 apho isakhiwo se-indole esisisiseko sitshintshwa ngesiseko se-indazole.

Iziphumo zomzimba

Ukuziva komzimba okuzenzekelayo

"Umzimba ophezulu" we-5F-AKB48 unokuchazwa njengento ebukhali, engathandekiyo, ehlanganiswe yonke into, kunye ne-electric tingling sensation esasazeka phezu komzimba emva kokungena kokuqala.Igcina ubukho obuhambelanayo obunyuka ngokukhawuleza ngokuqala kwaye ibethe umda wayo emva kokuba incopho ifikeleleke ngaphambi kokuchithwa ngokukhawuleza.

Ilahleko yolawulo lweemoto -

Le nto ibangela ucinezelo oluyinxenye ukuya koluphakathi lolawulo lwemoto oluqinisa umlinganiselo wethamo, kodwa kunqabile ukuba lube nesiphumo sokungakwazi ngokupheleleyo ukuhamba kunye nokwenza iintshukumo ezisisiseko.

Ukwandiswa kokutya

Njengamanye amaninzi e-cannabinoids, i-5F-AKB48 ibangela ukwanda kokutya, eyaziwa ngokuba yi "munchies" kwinkcubeko yaseMelika kunye ne-United Kingdom.Izifundo zeklinikhi kunye nedatha yophando ifumanise ukuba i-cannabis yonyusa ukonwabela ukutya kunye nomdla ekutyeni.Oku kucingelwa ukuba kubangelwa indlela i-endocannabinoids kwi-hypothalamus isebenze i-receptors ye-cannabinoid ejongene nokugcina ukutya.

Ukuphelisa iintlungu

I-Cannabinoids ibonakaliswe ngokweklinikhi ukuba ibonelele isiqabu kwiintlungu nge-agonism ye-cannabinoid receptors CB₁kunye ne-CB₂, eyandisa kwi-synthetic cannabinoid receptor agonists.

Ukubona ukukhanya komzimba

Utshintsho kumxhuzulane

Ukuphelelwa ngamanzi emzimbeni

Oku kwaziwa ngokuba "ngumlomo womqhaphu" kwinkcubeko edumileyo yaseMelika naseUnited Kingdom.

I-Vasodilation