Argipressin CAS: 113-79-1 AVP BETA-HYPOPHAMINE

[Arg8] -Isisombululo seVasopressin sasetyenziswa njenge-antigen ukulungiselela i-preadsorbed antisera ye-immunocytochemistry.Imveliso yayisetyenziswe kwinkcubeko ye-L6 yeseli ye-C5 subclone kwizifundo zokwahlula.

Ngenxa yokuba izinzile, i-desmopressin ikhethwa kunyango ngakumbi ukuba iziphumo zoxinzelelo azifunwa.Esona sibonakaliso siphambili sonyango sisifo seswekile insipidus esisembindini, ingxaki ebangelwa kukuba i-ADH secretion iyancipha kwaye ibonakaliswa yi-polydipsia, i-polyuria, kunye nokuphelelwa ngamanzi emzimbeni.I-Desmopressin ikwasetyenziselwa ukunciphisa i-primary nocturnal enuresis, okanye ukuchama ebhedini, ebantwaneni.Iluncedo kubantu abane-hemophilia epholileyo A okanye abaneentlobo ezithile zesifo sika-von Willebrand, apho i-von Willebrand factor ikhona kumanqanaba aphantsi.Kwezi meko, i-desmopressin inikwa xa kuphuma ukopha kakhulu okanye phambi kotyando ukunceda ukunciphisa ukopha ngokungangqalanga ngokwandisa inani lemiba ye-coagulation.Isiphumo esibi esinokubakho se-desmopressin kukunxila kwamanzi ukuba kuthathwe kakhulu.
Abachasi be-ADH, kubandakanywa ne-nonpeptide analogues ezinokuthi zithathwe ngomlomo, ziye zaphuhliswa ngokuthe ngqo kwintlobo nganye ye-receptor.Kwixesha elizayo, ezo zivimba i-V1 receptors zinokuba luncedo ekuphatheni i-hypertension, kwaye ezo zivimba i-V2 receptors zinokuba luncedo kuyo nayiphi na imeko yokugcinwa kwamanzi amaninzi okanye i-hyponatremia, okwangoku akukho unyango olwanelisayo lonyango.